Author

M. S. Wang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Assay:imaging· 3 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Approach:microscopy & imaging analysis· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

M. Huse· 3 shared F. Tamzalit· 2 shared L. C. Kam· 2 shared M. de Jesus· 2 shared W. Jin· 2 shared A. H. Settle· 1 shared B. Y. Winer· 1 shared C. Karas· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

M. Huse

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Topographical analysis of immune cell interactions reveals a biomechanical signature for immune cytolysis

M. de Jesus, A. H. Settle, D. Vorselen, T. K. Gaetjens, M. Galiano, Y. Y. Wong, T.-M. Fu, E. Santosa, B. Y. Winer, F. Tamzalit, M. S. Wang, Z. Bao, J. C. Sun, P. Shah, J. A. Theriot, , M. Huse

The paper analyzes immune cell interactions using traction force microscopy to identify biomechanical features associated with cytotoxic T cell activity.

bioRxiv · Apr 16, 2023 · PreprintImmunology

Selection of a Promiscuous Minimalist cAMP Phosphodiesterase from a Library of De Novo Designed Proteins

J. D. Schnettler, M. S. Wang, M. Gantz, C. Karas, M. H. Hecht, F. Hollfelder

The paper screens a library of de novo designed proteins to identify a promiscuous cAMP phosphodiesterase, finding that truncation and structural dynamics enable catalytic activity.

bioRxiv · Feb 13, 2023Biochemistry

Mechanically active integrins direct cytotoxic secretion at the immune synapse

M. S. Wang, Y. Hu, E. Sanchez, X. Xie, N. H. Roy, M. De Jesus, W. Jin, J. H. Lee, Y. Hong, M. Kim, L. C. Kam, K. Salaita, M. Huse

This study identifies integrin mechanotransduction as essential for directing cytotoxic secretion at the immune synapse, showing that mechanical forces from LFA-1 guide lytic granule fusion and cytotoxicity.

bioRxiv · Oct 2, 2021 · PreprintImmunology

Interfacial actin protrusions mechanically potentiate killing by cytotoxic T cells

F. Tamzalit, M. S. Wang, W. Jin, V. Boyko, J. M. Heddleston, C. T. Black, L. C. Kam, M. Huse

Cytotoxic T cells use actin-rich protrusions at immunological synapses to enhance perforin and granzyme-mediated killing of target cells.

bioRxiv · Oct 14, 2018Immunology