Author

B. T. Castle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

D. J. Odde· 2 shared E. Rhoades· 1 shared J. N. Sachs· 1 shared K. M. McKibben· 1 shared M. Hemmat· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 6 mutual co-author links

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2 shared papersCell Biology

D. J. Odde

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2 papers

Recent·Most cited

Tau avoids the GTP cap at growing microtubule plus ends

B. T. Castle, K. M. McKibben, E. Rhoades, D. J. Odde

This paper shows that tau preferentially binds GDP-tubulin over GTP-tubulin, causing it to lag behind microtubule plus-ends and suppress shortening rather than promote growth.

iScience · Dec 1, 2020Peer-reviewedCell Biology

Multi-scale Computational Modeling of Tubulin-Tubulin Lateral Interaction

M. Hemmat, B. T. Castle, J. N. Sachs, D. J. Odde

This study uses multi-scale modeling to show that lateral tubulin interactions are not the main driver of microtubule dynamic instability, linking atomistic simulations to cellular behavior.

bioRxiv · Apr 30, 2019Biophysics