M. Hoffmann

Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during periods of clinical latency

The paper identifies IL6 trans-signaling as a mechanism supporting DCC survival and outgrowth during clinical latency, with microenvironmental dependencies and PIK3CA mutations linked to metastatic progression.

Microbe-dependent heterosis in maize

This study shows that maize heterosis for root biomass and germination depends on soil microbes, as inbred lines perform as well as F1 hybrids under sterile conditions but not when microbes are present.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-domain Camelid Antibodies

This study isolates and characterizes VHH antibodies that neutralize MERS-CoV, SARS-CoV-1, and SARS-CoV-2 by blocking receptor binding, with structural insights into their epitopes and cross-reactivity.

How many bird and mammal extinctions has recent conservation action prevented?

The paper estimates that conservation actions prevented 21-32 bird and 7-16 mammal extinctions between 1993-2020, and 9-18 bird and 2-7 mammal extinctions between 2010-2020.

Global priorities for conservation of reptilian phylogenetic diversity in the face of human impacts

The paper develops metrics combining phylogenetic diversity and human impact for reptile conservation, finding high human impact areas coincide with high reptilian diversity and identifying data-deficient species as high priority.

A putative microcin amplifies Shiga toxin 2a production of Escherichia coli O157:H7

This paper identifies a microcin produced by E. coli 0.1229 that enhances Shiga toxin 2a production in E. coli O157:H7 through a mechanism involving the SOS response.

Reactive SINDy: Discovering governing reactions from concentration data

This paper introduces reactive SINDy, a method to estimate reaction networks from time series data, and demonstrates its application to gene regulation networks.

ReaDDy 2: Fast and flexible software framework for interacting-particle reaction dynamics

ReaDDy 2 is a software framework for simulating interacting-particle reaction dynamics, offering efficient and flexible simulation capabilities with Python and C++ interfaces.

Retrospective whole-genome sequencing analysis distinguished PFGE and drug resistance matched retail meat and clinical Salmonella isolates

This study used whole-genome sequencing to compare retail meat and clinical Salmonella isolates, revealing genetic differences and antimicrobial resistance patterns.