Design of novel Cyanovirin-N variants by modulation of binding dynamics through distal mutations
I. C. Kazan, P. Sharma, M. I. Rahman, A. A. Bobkov, R. Fromme, G. Ghirlanda, S. B. Ozkan
The paper introduces an ICDC approach to identify distal mutations that modulate protein function through dynamic allostery, validated on TEM-1 β-lactamase and applied to Cyanovirin-N.
bioRxiv · Dec 21, 2020Biophysics