Author

R. Fromme

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 4 Assay:structural biology· 3 Organism:bacteria (other)· 2 Assay:protein structure· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Organism:human· 1

Frequent Co-Authors

P. Fromme· 4 shared G. Nelson· 2 shared J. M. Martin-Garcia· 2 shared M. S. Hunter· 2 shared N. Nagaratnam· 2 shared N. Zatsepin· 2 shared T. D. Grant· 2 shared T. Grant· 2 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersBiochemistry

P. Fromme

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Author profile →

5 papers

Recent·Most cited

Minimized Sample Consumption for Time-Resolved Serial Crystallography Applied to the Redox Cycle of Human NQO1

D. Doppler, A. Grieco, D. Koh, A. Manna, A. Ansari, R. Alvarez, K. Karpos, H. Le, M. Sonker, G. Ketawala, S. Mahmud, I. Quereda Moraleda, A. L. Pey, R. Letrun, K. Doerner, , A. Ros

This paper demonstrates a method to reduce sample consumption in time-resolved serial crystallography by using segmented droplet generation and mix-and-inject approaches for studying NQO1's redox cycle.

bioRxiv · Apr 29, 2024Biochemistry

Detection of a geminate photoproduct of bovine cytochrome c oxidase by time-resolved serial femtosecond crystallography

S.-R. Yeh, I. Ishigami, D. L. Rousseau, S. Carbajo, N. Zatsepin, J. Coe, M. Hikita, M. H. Seaberg, R. G. Sierra, M. S. Hunter, P. Fromme, R. Fromme, G. Nelson, T. Grant, S. Basu, C. Conrad

The paper detects a geminate photoproduct of bovine cytochrome c oxidase using time-resolved serial femtosecond crystallography, revealing the ligand dissociation trajectory and protein dynamics.

bioRxiv · May 8, 2023Biophysics

Structural and biophysical properties of FopA, a major outer membrane protein of Francisella tularensis

P. Fromme, N. Nagaratnam, J. M. Martin-Garcia, J.-H. Yang, M. R. Goode, G. Ketalawa, F. M. Craciunescu, J. D. Zook, T. D. Grant, R. Fromme, D. T. Hansen

This study determines the structural and biophysical properties of FopA, a major outer membrane protein of Francisella tularensis, revealing its dimeric, two-domain organization.

bioRxiv · Apr 8, 2022Biochemistry

Design of novel Cyanovirin-N variants by modulation of binding dynamics through distal mutations

I. C. Kazan, P. Sharma, M. I. Rahman, A. A. Bobkov, R. Fromme, G. Ghirlanda, S. B. Ozkan

The paper introduces an ICDC approach to identify distal mutations that modulate protein function through dynamic allostery, validated on TEM-1 β-lactamase and applied to Cyanovirin-N.

bioRxiv · Dec 21, 2020Biophysics

Enzyme Intermediates Captured "on-the-fly" by Mix-and-Inject Serial Crystallography

J. Olmos, S. Pandey, J. M. Martin-Garcia, G. Calvey, A. Katz, J. Knoska, C. Kupitz, M. S. Hunter, M. Liang, D. Oberthuer, O. Yefanov, M. Wiedorn, M. Heymann, M. Holl, K. Pande, , Our

This paper demonstrates a method to capture enzyme reactions in real-time using mix-and-inject serial crystallography, revealing antibiotic cleavage and kinetic transitions in Mycobacterium tuberculosis β-lactamase.

bioRxiv · Jan 18, 2018Biophysics