Author

I. C. Kazan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

S. B. Ozkan· 2 shared A. A. Bobkov· 1 shared G. Ghirlanda· 1 shared M. I. Rahman· 1 shared N. J. Ose· 1 shared P. J. Campitelli· 1 shared P. Sharma· 1 shared R. Fromme· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

S. B. Ozkan

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2 papers

Recent·Most cited

Some mechanistic underpinnings of molecular adaptations of SARS-COV-2 spike protein by integrating candidate adaptive polymorphisms with protein dynamics

N. J. Ose, P. J. Campitelli, T. Modi, I. C. Kazan, S. Kumar, S. B. Ozkan

The paper integrates evolutionary predictions with protein dynamics to analyze molecular adaptations of SARS-CoV-2 Spike protein, revealing allosteric interactions and mutation effects on ACE2 binding and antibody escape.

bioRxiv · Sep 14, 2023Biophysics

Design of novel Cyanovirin-N variants by modulation of binding dynamics through distal mutations

I. C. Kazan, P. Sharma, M. I. Rahman, A. A. Bobkov, R. Fromme, G. Ghirlanda, S. B. Ozkan

The paper introduces an ICDC approach to identify distal mutations that modulate protein function through dynamic allostery, validated on TEM-1 β-lactamase and applied to Cyanovirin-N.

bioRxiv · Dec 21, 2020Biophysics