Author

M. Irla

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

M. Giraud· 2 shared F. Padonou· 1 shared J. Charaix· 1 shared J. Maslovskaja· 1 shared K. Kisand· 1 shared N. Boucherit· 1 shared N. Jmari· 1 shared N. Lopes· 1 shared

Activity by Year

2020-2021 · peak 1/yr

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10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

M. Giraud

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2 papers

Recent·Most cited

Aire-dependent transcripts escape H3K36me3 and Raver2 induced alternative splicing to sustain central immune tolerance

F. Padonou, V. Gonzalez, N. Jmari, J. Maslovskaja, K. Kisand, P. Peterson, M. Irla, M. Giraud

The paper identifies that Aire-sensitive genes in mTECs escape Raver2 and H3K36me3 regulation, leading to reduced alternative splicing and impacting central immune tolerance.

bioRxiv · Apr 8, 2021Immunology

Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages

N. Lopes, N. Boucherit, J. Charaix, P. Ferrier, M. Giraud, M. Irla

The paper shows self-reactive CD4+ thymocytes regulate gene expression and subset composition in immature medullary thymic epithelial cells through histone modifications and transcriptional regulators.

bioRxiv · Nov 29, 2020Immunology