A novel nuclear speckle factor, USP42, promotes homologous recombination repair by resolving DNA double-strand break induced R-loop
M. Matsui, R. Sakasai, M. Abe, Y. Kimura, S. Kajita, W. Torii, Y. Katsuki, M. Ishiai, K. Iwabuchi, M. Takata, R. Nishi
This study identifies USP42 as a nuclear speckle factor that promotes homologous recombination repair by resolving R-loops and facilitating BRCA1 recruitment to DNA double-strand breaks.
bioRxiv · Sep 20, 2019 · PreprintCell Biology