Impact of charge patches on tumor disposition and biodistribution of therapeutic antibodies
J. C. Stueber, K. F. Rechberger, S. M. Miladinovic, T. Poeschinger, T. Zimmermann, R. Villenave, M. J. Eigenmann, T. E. Kraft, D. K. Shah, H. Kettenberger, W. F. Richter
This study examines how antibody surface charge affects tumor uptake and biodistribution, finding that positive charges enhance tumor uptake but increase serum clearance.
bioRxiv · Sep 1, 2021Cancer Biology