Aberrant activation of wound healing programs within the metastatic niche facilitates lung colonization by osteosarcoma cells
J. B. Reinecke, L. Jimenez Garcia, A. C. Gross, M. Cam, M. V. Cannon, M. J. Gust, J. P. Sheridan, B. E. Gryder, R. Dries, R. D. Roberts
This study identifies fibrosis as a targetable vulnerability in osteosarcoma lung metastasis by showing nintedanib inhibits metastatic progression through anti-fibrotic effects.
bioRxiv · Jan 10, 2024Cancer Biology