R. D. Roberts

Trabectedin Enhances Oncolytic Virotherapy by Reducing Barriers to Virus Spread and Cytotoxic Immunity in Preclinical Pediatric Bone Sarcoma

This study shows trabectedin enhances oncolytic virotherapy by reducing anti-viral barriers and boosting immune-mediated tumor regression in preclinical models.

Aberrant activation of wound healing programs within the metastatic niche facilitates lung colonization by osteosarcoma cells

This study identifies fibrosis as a targetable vulnerability in osteosarcoma lung metastasis by showing nintedanib inhibits metastatic progression through anti-fibrotic effects.

Single-cell RNA Sequencing Reveals Immunosuppressive Myeloid Cell Diversity and Restricted Cytotoxic Effector Cell Trafficking and Activation During Malignant Progression in Glioma

This study uses single-cell RNA sequencing to analyze immune cell changes during glioma progression, identifying immunosuppressive myeloid cell subsets and potential therapeutic targets.

Structurally complex osteosarcoma genomes exhibit limited heterogeneity within individual tumors and across evolutionary time

This study analyzes SCNAs in osteosarcoma using single-cell DNA sequencing, finding limited heterogeneity and suggesting early catastrophic events drive genomic complexity.

Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization

This study shows osteosarcoma tumors retain transcriptional heterogeneity during bone and lung colonization despite selective pressures.