Author

M. J. LeClaire

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 1 Organism:mouse· 1 Assay:protein sequence· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

C. L. Mora· 2 shared J. Angeles· 2 shared J. B. Nice· 2 shared K. Elliott· 2 shared M. Cacciottolo· 2 shared M. Sun· 2 shared M. Young· 2 shared R. Twaddle· 2 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

C. L. Mora

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2 papers

Recent·Most cited

Nanograms of SARS-CoV-2 Spike Protein Delivered by Exosomes Induce Potent Neutralization of Both Delta and Omicron Variants.

M. Cacciottolo, Y. Li, J. B. Nice, M. J. LeClaire, R. Twaddle, C. L. Mora, S. Y. Adachi, M. Young, J. Angeles, K. Elliott, M. Sun

This study demonstrates that exosomes delivering nanogram amounts of SARS-CoV-2 Spike protein induce potent neutralization against Delta and Omicron variants and enhance T cell responses.

bioRxiv · Mar 20, 2023Immunology

Exosome based multivalent vaccine: achieving potent immunization, broadened reactivity, and strong T cell responses with nanograms of proteins

M. Cacciottolo, J. B. Nice, Y. Li, M. J. LeClaire, R. Twaddle, C. L. Mora, S. Y. Adachi, E. R. Chin, M. Young, J. Angeles, K. Elliott, M. Sun

This paper develops a multivalent exosome-based vaccine using nanogram doses of SARS-CoV-2 proteins without adjuvant, showing strong immune responses and cross-reactivity against variants.

bioRxiv · Jan 10, 2023 · PreprintImmunology