Author

M. Janecek

Primary ORCID profile (0000-0003-0740-641X · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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M. JanecekiD1 paper · University of Cambridge

Biology Disciplines

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Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:multiome· 1 Research Focus:protein structure prediction· 1 Approach:simulation· 1

Frequent Co-Authors

J. Sponer· 3 shared P. Banas· 3 shared M. Otyepka· 2 shared P. Kuhrova· 2 shared V. Mlynsky· 2 shared A. Ke· 1 shared G. Bussi· 1 shared I. R. Price· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiophysics

J. Sponer

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3 papers

Recent·Most cited

Towards Convergence in Folding Simulations of RNA Tetraloops: Comparison of Enhanced Sampling Techniques and Effects of Force Field Corrections

V. Mlynsky, M. Janecek, P. Kuhrova, T. Frohlking, M. Otyepka, G. Bussi, P. Banas, J. Sponer

This study compares enhanced sampling techniques and force field corrections for RNA tetraloop folding simulations, finding that combining REST2 with ST-MetaD improves sampling efficiency and that force field modifications stabilize native states.

bioRxiv · Nov 30, 2021 · PreprintBiophysics

W-RESP: Well-Restrained Electrostatic Potential Derived Charges. Revisiting the Charge Derivation Model.

M. Janecek, P. Kuhrova, V. Mlynsky, M. Otyepka, J. Sponer, P. Banas

The paper improves the RESP charge model to better describe electrostatic potentials around molecules, particularly for aromatic heterocyclic compounds, enhancing nucleic acid force field performance.

bioRxiv · Sep 14, 2020Biophysics

Local-to-global signal transduction at the core of the Mn2+ sensing riboswitch

K. C. Suddala, I. R. Price, M. Janecek, P. Kührova, S. Dandpat, J. Sponer, P. Banas, A. Ke, N. G. Walter

The paper investigates the Mn2+ sensing yybP-ykoY riboswitch, revealing how local structural changes trigger global signal transduction through RNA dynamics.

bioRxiv · Feb 18, 2019Biophysics