Author

N. G. Walter

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Biochemistry· 1 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:bacteria (other)· 3 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Assay:fluorescence / live-cell microscopy· 2

Frequent Co-Authors

A. Johnson-Buck· 2 shared A. P. Jalihal· 2 shared M. Tewari· 2 shared A. Chauvier· 1 shared A. Graziadei· 1 shared A. Ke· 1 shared A. M. Chinnaiyan· 1 shared A. Parolia· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersBioengineering

A. Johnson-Buck

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Author profile →

8 papers

Recent·Most cited

Ultrasensitive amplification-free quantification of a methyl CpG-rich cancer biomarker by single-molecule kinetic fingerprinting

L. Dai, A. Johnson-Buck, P. W. Laird, M. Tewari, N. G. Walter

This paper develops an amplification-free method to quantify DNA methylation at the BCAT1 promoter with high sensitivity and specificity, enabling improved early detection of methylated cancer DNA biomarkers.

bioRxiv · Apr 6, 2024Bioengineering

Nanoscale domains govern local diffusion and aging within FUS condensates

G. Gao, E. R. Sumrall, N. G. Walter

This study uses single-molecule tracking to show that nanodomains within FUS condensates regulate diffusion and aging, influencing fibrilization and disease progression.

bioRxiv · Apr 1, 2024 · PreprintBiophysics

Molecular basis of mRNA delivery to the bacterial ribosome

M. W. Webster, A. Chauvier, H. Rahil, A. Graziadei, K. Charles, M. Takacs, C. Saint-Andre, J. Rappsilber, N. G. Walter, A. Weixlbaumer

This study investigates how bS1 facilitates mRNA delivery to the ribosome and enhances translation initiation by RNAP in bacteria.

bioRxiv · Mar 19, 2024Biochemistry

BNP-Track: A framework for superresolved tracking

I. Sgouralis, L. W. Q. Xu, A. P. Jalihal, N. G. Walter, S. Presse

BNP-Track extends superresolution to track multiple emitters dynamically without relying on photodynamics, achieving sub-50 nm localization accuracy in both in-cell and synthetic data.

bioRxiv · Apr 3, 2023Biophysics

Rapid Kinetic Fingerprinting of Single Nucleic Acid Molecules by a FRET-based Dynamic Nanosensor

K. Khanna, S. Mandal, A. T. Blanchard, M. Tewari, A. Johnson-Buck, N. G. Walter

This paper introduces iSiMREPS, a method for rapid, single-molecule detection of miRNAs and ctDNAs with high specificity and sensitivity, achieving detection in 10 seconds.

bioRxiv · Apr 6, 2021Biophysics

Multivalent proteins rapidly and reversibly phase-separate upon osmotic cell volume change

A. P. Jalihal, S. Pitchiaya, L. Xiao, P. Bawa, X. Jiang, K. Bedi, A. Parolia, M. Cieslik, M. Ljungman, A. M. Chinnaiyan, N. G. Walter

The paper shows multivalent proteins rapidly phase-separate during hyperosmotic stress and reversibly dissolve upon osmotic rescue, impacting transcription termination.

Molecular Cell · Sep 1, 2020Peer-reviewedCell Biology

Local-to-global signal transduction at the core of the Mn2+ sensing riboswitch

K. C. Suddala, I. R. Price, M. Janecek, P. Kührova, S. Dandpat, J. Sponer, P. Banas, A. Ke, N. G. Walter

The paper investigates the Mn2+ sensing yybP-ykoY riboswitch, revealing how local structural changes trigger global signal transduction through RNA dynamics.

bioRxiv · Feb 18, 2019Biophysics

Ligand Modulates Cross-Coupling between Riboswitch Folding and Transcriptional Pausing

J. R. Widom, Y. A. Nedialkov, V. Rai, R. Hayes, C. L. Brooks, I. Artsimovitch, N. G. Walter

The paper investigates how ligand binding affects the interaction between riboswitch folding and transcriptional pausing in bacterial RNA polymerase.

bioRxiv · Jun 19, 2018Biophysics