A mutational atlas for Parkin proteostasis
L. Clausen, V. Voutsinos, M. Cagiada, K. E. Johansson, M. Gronbaek-Thygesen, S. Nariya, R. L. Powell, M. K. Have, V. H. Oestergaard, A. Stein, D. M. Fowler, K. Lindorff-Larsen, R. Hartmann-Petersen
This study maps Parkin missense variants' abundance and degradation mechanisms, showing most low-abundance variants are degraded via the ubiquitin-proteasome system and stabilized at lower temperatures.
bioRxiv · Jun 8, 2023Biochemistry