Author

M. Gronbaek-Thygesen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

K. Lindorff-Larsen· 3 shared R. Hartmann-Petersen· 3 shared A. Stein· 2 shared C. Kampmeyer· 2 shared L. Clausen· 2 shared M. Cagiada· 2 shared C. Andreasson· 1 shared D. M. Fowler· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

K. Lindorff-Larsen

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A mutational atlas for Parkin proteostasis

L. Clausen, V. Voutsinos, M. Cagiada, K. E. Johansson, M. Gronbaek-Thygesen, S. Nariya, R. L. Powell, M. K. Have, V. H. Oestergaard, A. Stein, D. M. Fowler, K. Lindorff-Larsen, R. Hartmann-Petersen

This study maps Parkin missense variants' abundance and degradation mechanisms, showing most low-abundance variants are degraded via the ubiquitin-proteasome system and stabilized at lower temperatures.

bioRxiv · Jun 8, 2023Biochemistry

Lysine deserts prevent adventitious ubiquitylation of ubiquitin-proteasome components

C. Kampmeyer, M. Gronbaek-Thygesen, N. Oelerich, M. H. Tatham, M. Cagiada, K. Lindorff-Larsen, W. Boomsma, K. Hofmann, R. Hartmann-Petersen

The paper identifies lysine deserts in UPS proteins and shows that introducing lysines increases ubiquitylation, with functional consequences for protein stability and function.

bioRxiv · Dec 8, 2022Biochemistry

Evolutionarily conserved chaperone-mediated proteasomal degradation of a disease-linked aspartoacylase variant

S. K. Gersing, Y. Wang, M. Gronbaek-Thygesen, C. Kampmeyer, L. Clausen, C. Andreasson, A. Stein, K. Lindorff-Larsen, R. Hartmann-Petersen

This study investigates the degradation pathway of a disease-linked ASPA variant, finding it is degraded via the proteasome and dependent on Hsp70 and Hsp110.

bioRxiv · Sep 4, 2020Biochemistry