Activation of bone marrow adaptive immunity in type 2 diabetes: rescue by co-stimulation modulator Abatacept
m. Santopaolo, N. Sullivan, A. Thomas, V. V. Alvino, L. Nicholson, Y. Gu, G. Spinetti, M. Kallikourdis, A. Blom, P. Madedddu
This paper investigates adaptive immune activation in bone marrow of T2D patients and mice, showing that Abatacept reduces T cell activation and improves cardiac function.
bioRxiv · Jul 3, 2020Immunology