Cancer BiologybioRxiv
Systematic Elucidation and Pharmacological Targeting of Tumor-Infiltrating Regulatory T Cell Master Regulators
A. Obradovic, C. Ager, M. Turunen…·A. Califano
The paper identifies 17 master regulators of tumor-infiltrating regulatory T cells (TI-Tregs) and shows that targeting TRPS1 reduces tumor growth and enhances PD-1 inhibitor efficacy.
DOI 10.1016/j.ccell.2023.04.003