A pipeline for rapidly generating genetically engineered mouse models of pancreatic cancer using in vivo CRISPR-Cas9 mediated somatic recombination
N. Ideno, H. Yamaguchi, T. Okumara, J. Huang, M. J. Brun, M. L. Ho, J. Suh, S. Gupta, A. Maitra, B. Ghosh
This paper develops a CRISPR-Cas9-based pipeline to generate pancreatic cancer mouse models with complex genotypes using AAV-delivered sgRNAs in adult mice.
Laboratory Investigation · Aug 1, 2019Peer-reviewedCancer Biology