Allele-specific activation, enzyme kinetics, and inhibitor sensitivities of EGFR exon 19 deletion mutations in lung cancer
B. P. Brown, Y. Zhang, S. Kim, P. Finneran, Y. Yan, Z. Du, J. Kim, A. L. Hartzler, M. L. LeNoue-Newton, A. W. Smith, J. Meiler, C. M. Lovly
The paper identifies allele-specific functional differences among EGFR exon 19 deletion variants, showing how sequence and structure motifs affect oncogenic activity, dimerization, and TKI sensitivity.
bioRxiv · Mar 16, 2022Cancer Biology