Author

B. P. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 3 Research Focus:drug response / drug discovery· 2 Assay:metagenomics· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. Meiler· 3 shared H. B. Jaspan· 2 shared A. A. Mamun· 1 shared A. B. Hanker· 1 shared A. L. Hartzler· 1 shared A. Marin· 1 shared A. Ssemata· 1 shared A. Varsani· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersCancer Biology

J. Meiler

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Approximating conformational Boltzmann distributions with AlphaFold2 predictions

B. P. Brown, R. A. Stein, J. Meiler, H. Mchaourab

This study shows AlphaFold2 contact distance distributions can approximate conformational Boltzmann distributions and predict mutation effects in some protein systems.

bioRxiv · Aug 6, 2023Biophysics

Acquired secondary HER2 mutations enhance HER2/MAPK signaling and promote resistance to HER2 kinase inhibition in HER2-mutant breast cancer

A. Marin, A. A. Mamun, H. Akamatsu, D. Ye, d. R. Sudhan, B. P. Brown, L. Eli, K. Marcelain, J. Meiler, C. L. Arteaga, A. B. Hanker

This study identifies secondary HER2 mutations that confer resistance to HER2 kinase inhibitors in HER2-mutant breast cancer by enhancing HER2 signaling and reducing drug binding.

bioRxiv · Sep 23, 2022 · PreprintCancer Biology

Bacterial Microbiome and Host Inflammatory Gene Expression in Foreskin Tissue

B. S. Maust, S. Petkov, C. Herrera, C. Feng, B. P. Brown, L. Lebina, D. Opoka, A. Ssemata, N. Pillay, J. Serwanga, P. Seatlholo, P. Namubiru, G. Odoch, S. Mugaba, T. Seiphetlo, , the CHAPS team

The paper analyzes the foreskin microbiome and host gene expression in adolescents from South Africa and Uganda, finding no treatment effect on bacterial communities but inverse correlations between bacterial abundance and inflammatory gene expression.

bioRxiv · Aug 29, 2022Microbiology

Allele-specific activation, enzyme kinetics, and inhibitor sensitivities of EGFR exon 19 deletion mutations in lung cancer

B. P. Brown, Y. Zhang, S. Kim, P. Finneran, Y. Yan, Z. Du, J. Kim, A. L. Hartzler, M. L. LeNoue-Newton, A. W. Smith, J. Meiler, C. M. Lovly

The paper identifies allele-specific functional differences among EGFR exon 19 deletion variants, showing how sequence and structure motifs affect oncogenic activity, dimerization, and TKI sensitivity.

bioRxiv · Mar 16, 2022Cancer Biology

Qualification of ELISA and neutralization methodologies to measure SARS-CoV-2 humoral immunity using human clinical samples

S. E. Larsen, B. J. Berube, T. Pecor, E. Cross, B. P. Brown, B. Williams, E. Johnson, P. Qu, L. Carter, S. Wren, E. Kepl, C. Sydeman, N. P. King, S. L. Baldwin, R. N. Coler

This paper qualifies ELISA and neutralization assays to measure SARS-CoV-2 humoral immunity using clinical samples, evaluating antibody titers and functional neutralization capacity.

bioRxiv · Jul 2, 2021Immunology

crAssphage abundance and genomic selective pressure correlate with altered bacterial abundance in the fecal microbiota of South African mother-infant dyads

B. P. Brown, J. Wendoh, D. Chopera, E. Havyarimana, S. Z. Jaumdally, D. D. Nyangahu, C. Gray, D. P. Martin, A. Varsani, H. B. Jaspan

The paper investigates crAssphage transmission and genomic evolution in South African mother-infant dyads, finding evidence of vertical transmission and positive selection in phage genes correlated with bacterial abundance.

bioRxiv · Mar 19, 2019 · PreprintMicrobiology