Downregulation of Neurodevelopmental Gene Expression in iPSC-Derived Cerebral Organoids Upon Infection by Human Cytomegalovirus
B. S. O'Brien, R. L. Mokry, M. L. Schumacher, K. Pulakanti, S. Rao, S. S. Terhune, A. D. Ebert
This study shows HCMV infection reduces neurodevelopmental gene expression in cerebral organoids, even when IE proteins are disrupted, suggesting alternative viral mechanisms drive the effect.
bioRxiv · Aug 1, 2021Cell Biology