S. Rao

Antibody responses in Klebsiella pneumoniae bloodstream infection: a cohort study

This study examines antibody responses to Klebsiella pneumoniae OPS antigens in bloodstream infections, finding high immunogenicity and cross-reactivity but also capsule-mediated inhibition of antibody function.

Cardiovascular symptoms of PASC are associated with trace-level cytokines that affect the function of human pluripotent stem cell derived cardiomyocytes

This study identifies trace-level cytokines in PASC patients linked to cardiovascular symptoms and shows their impact on cardiomyocyte function using nanotechnology detection.

Defining the constituents and functions of a lipid-based jumbo phage compartment

The paper identifies a lipid-based compartment in early phage infection that protects phage DNA and supports early transcription and translation.

Biologically Driven In Vivo Occlusion Design Provides a Reliable Experimental Glaucoma Mouse Model

This paper develops a biologically inspired microbead platform for inducing chronic ocular hypertension in mice, leading to retinal ganglion cell loss and visual pathway impairment.

Mechanism and cellular function of direct membrane binding by the ESCRT and ERES-associated Ca2+-sensor ALG-2

This study investigates how ALG-2 binds membranes and proteins in a Ca2+-dependent manner, revealing its role in membrane repair and ERES function.

Structural pathway for class III PI 3-kinase activation by the myristoylated GTP-binding pseudokinase VPS15

This study maps the structural pathway of class III PI 3-kinase activation by showing how N-myristoylation of VPS15 stabilizes the inactive conformation and how GTP binding promotes activation.

PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency

This study identifies PCID2 as a novel HIV-1 latency-promoting factor that represses transcription and dysregulates viral RNA processing through its role in the TREX2 complex.

Three-step docking by WIPI2, ATG16L1 and ATG3 delivers LC3 to the phagophore

The paper identifies three sequential steps by which the ATG12-ATG5-ATG16L1 complex delivers LC3 to the phagophore via WIPI2, ATG16L1, and ATG3.

SQuHIVLa: A novel assay for Specific Quantification of inducible HIV-1 reservoir by LAMP

SQuHIVLa quantifies inducible HIV-1 reservoirs in CD4+ T cells using a sensitive and specific RT-LAMP assay, showing high throughput and scalability.

Oxidation of hemoproteins by Streptococcus pneumoniae collapses the cell cytoskeleton and disrupts mitochondrial respiration leading to cytotoxicity of human lung cells

This study shows that Streptococcus pneumoniae produces H2O2, which oxidizes hemoproteins like hemoglobin and cytochrome c, leading to mitochondrial dysfunction and cell death in human lung cells.

Unpredictable soil conditions affect the prevalence of a microbial symbiosis

The study examines how unpredictable soil conditions influence the prevalence of microbial symbiosis in Dictyostelium discoideum, finding that precipitation unpredictability affects Paraburkholderia symbionts differently.

Supramolecular catch-and-release strategy for bioorthogonal fluorogenic imaging across the visible spectrum

This paper introduces a supramolecular catch-and-release strategy for bioorthogonal fluorogenic imaging using cucurbit[7]uril, enabling efficient and generalizable fluorogenic responses from diverse fluorophores without structural modifications.

N-MYC regulates Cell Survival via eIF4G1 in inv(16) Acute Myeloid Leukemia

The paper shows N-MYC promotes survival in inv(16) AML by regulating eIF4G1, identifying a novel MYCN enhancer and a new oncogenic role for eIF4G1 in AML.

Lower-limb Nonparametric Functional Muscle Network: Test-retest Reliability Analysis

This study evaluates the test-retest reliability of non-parametric lower-limb functional muscle networks in healthy subjects for controlled and lightly-controlled tasks.

Linear versus Nonlinear Muscle Networks: A Case Study to Decode Hidden Synergistic Patterns During Dynamic Lower-limb Tasks

This paper compares linear and nonlinear muscle networks during dynamic lower-limb tasks, finding that nonlinear networks better capture synergistic patterns in complex tasks like sit-to-stand.

H3.1Cys96 oxidation by mitochondrial ROS promotes chromatin remodeling, breast cancer progression to metastasis and multi-drug resistance

The paper shows that mitochondrial H2O2 oxidizes H3.1 at Cys96, promoting chromatin remodeling, breast cancer metastasis, and drug resistance.

The structure of yeast Npl3 bound to RNA reveals a cooperative sequence-specific recognition and an RNA chaperone role in splicing

This study determines the RNA-binding specificity of yeast Npl3's RRMs using NMR structures and shows its role in melting U2 snRNA for splicing.

The ATLAS™ screening assay reveals distinct CD4+ and CD8+ SARS-CoV-2 antigen response profiles which have implications to Omicron cellular immunity

The paper uses the ATLAS assay to identify CD4+ and CD8+ T cell antigen responses to SARS-CoV-2 variants, revealing common epitopes and predicting Omicron spike mutation impacts.

Membrane curvature sensing and stabilization by the autophagic LC3 lipidation machinery

The paper investigates how the LC3 lipidation machinery interacts with curved membranes during autophagy initiation, showing that ATG12-5-16L1 stabilizes membrane curvature.

B cell receptor repertoire analysis unveils dynamic antibody response and severity markers in COVID-19 patients

The paper analyzes B cell receptor repertoires in COVID-19 patients to identify antibody response dynamics and severity markers.

Mapping morphological malformation to genetic dysfunction in blood vessel organoids with 22q11.2 Deletion Syndrome

This study uses blood vessel organoids from 22q11.2 DS patients to link genetic dysfunction to vascular malformations through single-cell transcriptomics and imaging.

Downregulation of Neurodevelopmental Gene Expression in iPSC-Derived Cerebral Organoids Upon Infection by Human Cytomegalovirus

This study shows HCMV infection reduces neurodevelopmental gene expression in cerebral organoids, even when IE proteins are disrupted, suggesting alternative viral mechanisms drive the effect.

Water Nanoconfined in a Hydrophobic Pore: MD Simulations and Water Models

This study uses molecular dynamics simulations to show that polarisable water models enhance wettability in hydrophobic nanopores, affecting wetting/de-wetting behavior in ion channels.

Impaired T-cell and antibody immunity after COVID-19 infection in chronically immunosuppressed transplant recipients

This study evaluates T-cell and antibody immunity to SARS-CoV-2 in transplant recipients, finding impaired responses and increased CMV co-infection risk post-infection.

Immunogenic Potential of DNA Vaccine candidate, ZyCoV-D against SARS-CoV-2 in Animal Models

This study evaluates the immunogenic potential of the DNA vaccine ZyCoV-D against SARS-CoV-2 in animal models, showing antibody and Th-1 responses.

Arabidopsis cell surface LRR immune receptor signaling through the EDS1-PAD4-ADR1 node

This study identifies the EDS1-PAD4-ADR1 node as a convergence point for immune signaling in Arabidopsis, linking surface and intracellular LRR receptors.

Human liver organoids; a patient-derived primary model for HBV Infection and Related Hepatocellular Carcinoma

This paper establishes human liver organoids as a model for HBV infection and HCC, showing they support viral replication, produce infectious HBV, and exhibit cancer-related gene signatures.

Hyperoxia inhibits proliferation of retinal endothelial cells in Myc dependent manner

The paper shows hyperoxia inhibits retinal endothelial cell proliferation via Myc dependency, contributing to oxygen-induced retinopathy.

Multiple Mechanisms Underlie State-Independent Inhibitory Effects of Norfluoxetine on TREK-2 K2P Channels

This study identifies multiple mechanisms by which norfluoxetine inhibits TREK-2 K2P channels, showing state-independent effects and interactions with filter stability and voltage-dependent gating.

Generation of glucocorticoid resistant SARS-CoV-2 T-cells for adoptive cell therapy

The paper expands SARS-CoV-2 T-cells from COVID-19 donors using IL-2/4/7 cytokines, achieving >1000-fold expansion with preserved function, and inactivates the glucocorticoid receptor to create glucocorticoid-resistant T-cells for adoptive therapy.