HIV-1 and HIV-2 differentially regulate NF-κB activity during the late stages of the replication cycle through BST-2/tetherin antagonism
F. E. Dufrasne, G. Dessilly, M. Lucchetti, K. Soumillion, E. Ngyuvula, J. Ruelle, L. Tafforeau, M. Sanou, B. Kabamba-Mukadi
This paper shows HIV-2 less effectively inhibits NF-κB than HIV-1, leading to stronger antiviral immune responses due to Env-mediated BST-2/tetherin antagonism.
bioRxiv · May 11, 2020 · PreprintMicrobiology