Amyloid-β oligomers are captured by the DNAJB6 chaperone: Direct detection of interactions that can prevent primary nucleation
N. Österlund, M. Lundqvist, L. I. Ilag, A. Gräslund, C. Emanuelsson
This study shows DNAJB6 captures Aβ oligomers via S/T residues, inhibiting amyloid nucleation by binding pre-nucleation aggregates directly detected by native mass spectrometry.
bioRxiv · Mar 16, 2020Biochemistry