A minimal RNA ligand for potent RIG-I activation in living mice
M. M. Linehan, T. H. Dickey, E. S. Molinari, M. E. Fitzgerald, O. Potapova, A. Iwasaki, A. M. Pyle
This study develops synthetic RNA ligands that activate RIG-I in mice, inducing interferon responses and specific gene expression, and shows their potential as therapeutic tools.
bioRxiv · Aug 19, 2017Immunology