Author

M. M. Pinney

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

D. Herschlag· 2 shared F. Yabukarski· 2 shared A. S. Powers· 1 shared E. Pieri· 1 shared J. P. Schwans· 1 shared J. Parres-Gold· 1 shared J. S. Fraser· 1 shared J. T. Biel· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

D. Herschlag

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Conformational Ensembles Reveal the Origins of Serine Protease Catalysis

S. Du, R. C. Kretsch, J. Parres-Gold, E. Pieri, V. W. D. Cruzeiro, M. Zhu, M. M. Pinney, F. Yabukarski, J. P. Schwans, T. J. Martinez, D. Herschlag

Ensemble-function analyses provide a quantitative model for serine protease catalysis, reveal previously unknown conformational features that contribute to their catalysis, and identify a structural motif that underlie these features and has evolved in >100 different enzymes from 32 protein folds.

bioRxiv · Feb 28, 2024Biophysics

Assessment of enzyme active site positioning and tests of catalytic mechanisms through X-ray-derived conformational ensembles

F. Yabukarski, J. T. Biel, M. M. Pinney, T. Doukov, A. S. Powers, J. S. Fraser, D. Herschlag

This study uses X-ray crystallography to analyze enzyme active site positioning and motions, finding limited conformational changes and challenging existing catalytic mechanisms.

bioRxiv · Jun 4, 2020Biophysics