Author

J. T. Biel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Research Focus:protein structure prediction· 3 Assay:structural biology· 3 Research Focus:protein folding & dynamics· 2 Research Focus:benchmarking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. S. Fraser· 4 shared A. Douangamath· 2 shared A. E. Cohen· 2 shared D. A. Keedy· 2 shared F. von DelftiD· 2 shared I. D. Young· 2 shared M. C. Thompson· 2 shared A. Aimon· 1 shared

Activity by Year

2016-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiophysics

J. S. Fraser

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B

T. S. Mehlman, J. T. Biel, S. M. Azeem, E. R. Nelson, S. Hossain, L. E. Dunnett, N. G. Paterson, A. Douangamath, R. Talon, D. Axford, H. Orins, F. von Delft, D. A. Keedy

This study compares cryo and room-temperature crystallography of PTP1B with small-molecule fragments, showing RT reveals different binding modes and conformational changes.

bioRxiv · Nov 2, 2022Biophysics

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

M. Schuller, G. J. Correy, S. Gahbauer, D. Fearon, T. Wu, R. E. Diaz, I. D. Young, L. Carvalho Martins, D. H. Smith, U. Schulze-Gahmen, T. W. Owens, I. Deshpande, G. E. Merz, A. C. Thwin, J. T. Biel, , Smi

The paper identifies new chemical fragments binding to the SARS-CoV-2 Nsp3 macrodomain through crystallographic screening and computational docking, validating their binding with biophysical techniques.

bioRxiv · Nov 24, 2020Biochemistry

Assessment of enzyme active site positioning and tests of catalytic mechanisms through X-ray-derived conformational ensembles

F. Yabukarski, J. T. Biel, M. M. Pinney, T. Doukov, A. S. Powers, J. S. Fraser, D. Herschlag

This study uses X-ray crystallography to analyze enzyme active site positioning and motions, finding limited conformational changes and challenging existing catalytic mechanisms.

bioRxiv · Jun 4, 2020Biophysics

Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals

A. M. Wolff, I. D. Young, R. G. Sierra, A. S. Brewster, M. W. Martynowycz, E. Nango, M. Sugahara, T. Nakane, K. Ito, A. Aquila, A. Bhowmick, J. T. Biel, S. Carbajo, A. E. Cohen, S. Cortez, , M. C. Thompson

This study compares serial X-ray crystallography and MicroED for determining structures from small macromolecular crystals, highlighting their strengths and challenges.

bioRxiv · Sep 12, 2019Biophysics

New routes for PTP1B allosteric inhibition by multitemperature crystallography, fragment screening and covalent tethering

D. A. Keedy, Z. B. Hill, J. T. Biel, E. Kang, T. J. Rettenmaier, J. Brandao-Neto, N. M. Pearce, F. von Delft, J. A. Wells, J. S. Fraser

The paper identifies a new allosteric site in PTP1B using multitemperature crystallography and fragment screening, showing covalent tethering can inhibit enzyme activity.

bioRxiv · Nov 13, 2017Biophysics

Flexibility and design: conformational heterogeneity along the evolutionary trajectory of a redesigned ubiquitin

J. T. Biel, M. C. Thompson, C. N. Cunningham, J. E. Corn, J. S. Fraser

This study shows that increasing flexibility in designed proteins can help escape local minima during evolution, using redesigned ubiquitin variants with improved binding affinity to USP7.

bioRxiv · Oct 17, 2016Biophysics