IL-36/IL-36R Signaling Promotes CD4+ T Cell-Dependent Colitis via Pro-Inflammatory Cytokine Production
M. Maarouf, M. Kuczma, T. L. Denning
This study shows IL-36γ promotes colitis by enhancing CD4+ T cell cytokine production, specifically IFNγ and TNF, and suggests targeting these cytokines as a therapeutic strategy for IBD.
bioRxiv · May 24, 2023Immunology