In vivo diversification of target genomic sites using processive T7 RNA polymerase-base deaminase fusions blocked by RNA-guided dCas9
B. Alvarez, M. Mencia, V. de Lorenzo, L. A. Fernandez
This paper develops an in vivo system to diversify specific DNA segments using T7 RNA polymerase-base deaminase fusions blocked by RNA-guided dCas9, demonstrating efficiency in E. coli.
bioRxiv · Nov 22, 2019 · PreprintBioengineering