Mitochondrial complex III deficiency drives c-MYC overexpression and illicit cell cycle entry leading to senescence and segmental progeria
J. Purhonen, R. Banerjee, V. Wanne, N. Sipari, M. Morgelin, V. Fellman, J. Kallijarvi
This study shows that mitochondrial complex III deficiency causes c-MYC overexpression, leading to senescence and progeria-like symptoms in mice.
bioRxiv · Jan 10, 2023Pathology