Changes in calpain-2 expression during glioblastoma progression predisposes tumor cells to temozolomide resistance by minimizing DNA damage and p53-dependent apoptosis
M. N. Stillger, C.-Y. Chen, Z. W. Lai, M. Li, A. Schaefer, A. Pagenstecher, C. Nimsky, J. W. Bartsch, O. Schilling
This study shows that calpain-2 expression in glioblastoma cells reduces TMZ-induced DNA damage and p53-dependent apoptosis, leading to chemoresistance.
bioRxiv · Oct 19, 2022 · PreprintCancer Biology