CaMKII oxidation is a performance/disease trade-off in vertebrate evolution
Q. Wang, E. O. Hernandez-Ochoa, M. C. Viswanathan, I. D. Blum, J. M. Granger, K. R. Murphy, A.-C. Wei, S. Aja, N. Liu, C. M. Antonescu, L. D. Florea, C. C. Talbot, D. Mohr, K. R. Wagner, S. Regot, , M. E. Anderson
This study shows CaMKII oxidation by ROS evolved in vertebrates to enhance performance but increased disease risk.
bioRxiv · Sep 13, 2019Evolutionary Biology