Post-Translational Modifications Control Phase Transitions of Tau
W. Powell, M. Nahum, K. Pankratz, M. Herlory, J. Greenwood, D. Poliyenko, P. Holland, R. Jing, L. Biggerstaff, M. Stowell, M. Walczak
This study investigates how AD-specific post-translational modifications affect Tau self-assembly into PHFs, finding that phosphorylation generally inhibits aggregation while acetylation has variable effects.
bioRxiv · Mar 8, 2024Biophysics