Mechanical Instability of Adherens Junctions Overrides Intrinsic Quiescence of Hair Follicle Stem Cells
R. Biswas, A. Banerjee, S. Lembo, Z. Zhao, V. Lakshmanan, M. Nakasaki, V. Kutyavin, G. Wright, D. Palakodeti, R. Ross, C. Jamora, V. Vasioukhin, J. Yan, S. Raghavan
This study shows that vinculin loss in murine skin disrupts adherens junctions, leading to loss of bulge stem cell quiescence through impaired force generation and YAP1 retention.
bioRxiv · Jan 17, 2020Cell Biology