Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics
B. Khanppnavar, D. Schuster, P. Lavriha, F. Uliana, M. Özel, V. Mehta, A. Leitner, P. Picotti, V. M. Korkhov
The paper determines the cryo-EM structure of bovine AC8 bound to CaM and Gs, identifies interaction sites, and infers conformational changes in the regulation mechanism.
bioRxiv · Mar 3, 2023Biochemistry