Author

V. Mehta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:cryo-EM· 3 Assay:proteomics· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:protein structure prediction· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1

Frequent Co-Authors

B. Khanppnavar· 3 shared V. M. Korkhov· 3 shared D. Schuster· 2 shared L. Trinkle-Mulcahy· 2 shared P. Lavriha· 2 shared P. Picotti· 2 shared A. Andrabi· 1 shared A. Bashir· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersBiochemistry

B. Khanppnavar

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics

B. Khanppnavar, D. Schuster, P. Lavriha, F. Uliana, M. Özel, V. Mehta, A. Leitner, P. Picotti, V. M. Korkhov

The paper determines the cryo-EM structure of bovine AC8 bound to CaM and Gs, identifies interaction sites, and infers conformational changes in the regulation mechanism.

bioRxiv · Mar 3, 2023Biochemistry

Screening of herbal molecules for the management of Alzheimer's Disorder through molecular docking and in-vitro investigation

P. Nagu, A. K. A. Pathan, V. Mehta

This study screens 100 herbal molecules for Alzheimer's management using molecular docking and in-vitro assays, identifying quercetin and rutin as potential candidates for AChE, BChE, and neurodegeneration inhibition.

bioRxiv · Jan 1, 2023 · PreprintPharmacology & Toxicology

Evaluation of the safety, immunogenicity and efficacy of a new live-attenuated lumpy skin disease vaccine in India

N. Kumar, S. Barua, R. Kumar, N. Khandelwal, A. Kumar, A. Verma, L. Singh, B. Godara, Y. Chander, T. Riyesh, D. K. Sharma, A. Pathak, S. Kumar, R. K. Dedar, V. Mehta, , B. N. Tripathi

This study evaluates a new live-attenuated LSD vaccine, showing it is safe, immunogenic, and effective in protecting cattle against LSD with high seroconversion rates.

bioRxiv · Dec 10, 2022Microbiology

SPECC1L binds MYPT1/PP1β and can regulate its distribution between microtubules and filamentous actin

V. Mehta, N. Decan, A. Gaudreau-Lapierre, J. W. Copeland, L. Trinkle-Mulcahy

This paper identifies SPECC1L as a binding partner of MYPT1/PP1β and shows it regulates their distribution between microtubules and actin.

bioRxiv · Sep 9, 2022Cell Biology

Subcellular distribution of PP1 isoforms in holoenzyme complexes

V. Mehta, D. Chamousset, J. Law, S. Ooi, D. Campuzano, V. Nguyen, F.-M. Boisvert, G. B. Moorhead, L. Trinkle-Mulcahy

The paper maps PP1 isoform subcellular distribution through holoenzyme complexes using proteomic and biochemical methods, identifying c20orf27 as a novel regulatory protein and highlighting SDS22's role in PP1 localization.

bioRxiv · Sep 9, 2022 · PreprintCell Biology

Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases

V. Mehta, B. Khanppnavar, D. Schuster, I. Kantarci, I. Vercellino, A. Kosturanova, T. Iype, S. Stefanic, P. Picotti, V. M. Korkhov

The paper determines the cryo-EM structure of Mycobacterium tuberculosis Cya, revealing its TM domain's role in catalytic activity regulation.

bioRxiv · Dec 1, 2021Biochemistry

Structural basis of adenylyl cyclase 9 activation

C. Qi, P. Lavriha, V. Mehta, B. Khanppnavar, I. Mohammed, Y. Li, M. Lazaratos, J. V. Schaefer, B. Dreier, A. Plueckthun, A.-N. Bondar, C. W. Dessauer, V. M. Korkhov

The paper presents cryo-EM structures of AC9 in different states to reveal activator-induced conformational changes essential for its activation.

bioRxiv · Aug 11, 2021Biochemistry