Cellulonodin-2 and Lihuanodin: Lasso Peptides with an Aspartimide Post-Translational Modification
L. Cao, M. Beiser, J. D. Koos, M. Orlova, H. E. Elashal, H. V. Schroeder, A. J. Link
The paper identifies a new post-translational modification of lasso peptides by PIMT enzymes, which methylates aspartate residues and converts them to aspartimide, increasing ring rigidity.
bioRxiv · May 19, 2021Biochemistry