A. J. Link

A large-scale bioinformatic study of graspimiditides and structural characterization of albusimiditide

This paper identifies and classifies graspimiditides, a subclass of graspetides with aspartimide modifications, and characterizes the structure of albusimiditide.

Genome Mining and Discovery of Imiditides, a Novel Family of RiPPs with a Class-defining Aspartimide Modification

This paper discovers a novel family of RiPPs called imiditides through genome mining, revealing 670 BGCs and demonstrating heterologous production of mNmaAM with a unique aspartimide modification.

Discovery, Characterization, and Bioactivity of the Achromonodins: Lasso Peptides Encoded by Achromobacter

The paper discovers and characterizes two lasso peptides from Achromobacter species, showing one inhibits RNA polymerase and has antimicrobial activity against Achromobacter pulmonis.

A High-Throughput Screen Reveals the Structure-Activity Relationship of the Antimicrobial Lasso Peptide Ubonodin

This study uses a high-throughput screen to analyze ubonodin variants, identifying structure-activity relationships and a variant with improved antimicrobial activity against Burkholderia cenocepacia.

The Anti-Burkholderia Lasso Peptide Ubonodin Co-Opts the Siderophore Receptor PupB for Cellular Entry

This study identifies PupB as an outer membrane receptor required for ubonodin uptake in Burkholderia cepacia, revealing that transport, not target inhibition, determines its activity.

Fuscimiditide: a RiPP with {Omega}-Ester and Aspartimide Post-translational Modifications

This paper describes the discovery of a new family of omega-ester linked peptides, fuscimiditide, and characterizes its post-translational modifications and biosynthesis.

Cellulonodin-2 and Lihuanodin: Lasso Peptides with an Aspartimide Post-Translational Modification

The paper identifies a new post-translational modification of lasso peptides by PIMT enzymes, which methylates aspartate residues and converts them to aspartimide, increasing ring rigidity.