M. P. Licciardello

R-loop editing by DNA cytosine deaminase APOBEC3B determines the activity of estrogen receptor enhancers

This study shows APOBEC3B edits R-loops at ER enhancers, leading to DSBs that contribute to genomic instability in breast cancer.

Loss of Spindly sensitizes EML4-ALK v3 lung cancer cells to HSP90 inhibitors

The paper shows that loss of Spindly increases sensitivity of EML4-ALK v3 NSCLC cells to HSP90 inhibitors, but not v1 cells.