Heme-stress activated NRF2 signaling skews fate trajectories of bone marrow cells from dendritic cells towards red pulp-like macrophages
F. Vallelian, R. M. Buzzi, M. Pfefferle, A. Yalamanoglu, A. Wassmer, T. Gentinetta, K. Hansen, R. Humar, N. Schulthess, D. J. Schaer
This study shows heme-stress activates NRF2 signaling in bone marrow cells, shifting their differentiation from dendritic cells to red pulp-like macrophages, contributing to immunodeficiency in hemolytic diseases.
bioRxiv · Jul 29, 2021Immunology