K. Hansen

Ferroptosis regulates hemolysis in stored murine and human red blood cells

This study identifies Steap3 as a regulator of ferroptosis-like lipid peroxidation in stored RBCs, linking genetic variants to hemolysis in mice and human blood donors.

Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNA splicing and mitochondrial dysfunction in the budding yeast

The paper humanizes yeast U1 snRNP components to study 5 ss recognition, finding that U1C ZnF substitution causes splicing defects and mitochondrial dysfunction.

Ligand-induced conformational changes in the β1-Adrenergic Receptor Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry

This study uses HDX-MS to analyze structural dynamics of tβ1AR with different ligands, revealing ICL1 dynamics linked to GPCR activation and drug modality.

Cryo-EM structure and functional landscape of an RNA polymerase ribozyme

The paper determines the cryo-EM structure of a triplet polymerase ribozyme and maps its functional landscape using mutation analysis.

Heme-stress activated NRF2 signaling skews fate trajectories of bone marrow cells from dendritic cells towards red pulp-like macrophages

This study shows heme-stress activates NRF2 signaling in bone marrow cells, shifting their differentiation from dendritic cells to red pulp-like macrophages, contributing to immunodeficiency in hemolytic diseases.

Proteolytic Activation of Human-specific Olduvai Domains by the Furin Protease

The paper shows human-specific Olduvai domains are cleaved by furin protease, suggesting they function as proproteins activated by this processing, linking their expansion to human brain evolution.

Pro-regenerative Extracellular Matrix Hydrogel Prevents and Mitigates Pathological Alterations of Pelvic Muscles Following Birth Injury

This study shows that an extracellular matrix hydrogel prevents and reduces muscle atrophy and fibrosis in pelvic floor muscles after birth injury in rats.

Quantification of biologically and chemically bound phosphorus in activated sludge from full-scale plants with biological P-removal

This study quantifies different phosphorus fractions in activated sludge from EBPR plants using multiple analytical techniques and finds that polyphosphate constitutes a significant portion of total phosphorus, primarily stored in known polyphosphate-accumulating organisms.

Disparate effects of metformin on Mycobacterium tuberculosis infection in diabetic and non-diabetic mice

This study shows that metformin has different effects on tuberculosis infection in diabetic versus non-diabetic mice, with non-diabetic mice showing higher disease burden.

The interactome of the N-terminus of band 3 regulates red blood cell metabolism and storage quality

This paper investigates the role of the N-terminus of band 3 in red blood cell metabolism and storage quality using genetic models and proteomic analyses, showing its impact on metabolic pathways and transfusion outcomes.

Highly multiplexed oligonucleotide probe-ligation testing enables efficient extraction-free SARS-CoV-2 detection and viral genotyping

This paper introduces cRASL-seq, a method for sensitive and high-throughput SARS-CoV-2 detection and genotyping without nucleic acid extraction or reverse transcription.

Niche and neutral processes leave distinct structural imprints on indirect interactions in mutualistic networks

The paper examines indirect interactions in pollination networks using motif analysis, finding distinct structural patterns associated with neutral and niche-based processes.

Postpartum breast cancer progression is driven by semaphorin 7a mediated invasion and survival

This study shows SEMA7A drives postpartum breast cancer progression by enhancing invasion, survival, and tumor microenvironment changes, with potential therapeutic implications.

JMJD6 Cleaves MePCE to Release P-TEFb

The paper identifies JMJD6 as a protease that cleaves MePCE, releasing P-TEFb from the 7SK snRNP complex to enable Pol II-CTD phosphorylation.

Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors

This study identifies Y-acidic motifs recognized by KLC1TPR in kinesin-1, distinct from W-acidic motifs, and proposes a model for their differential activity promotion.