Mutant mice lacking alternatively spliced p53 isoforms unveil Ackr4 as a male-specific prognostic factor in Myc-driven B-cell lymphomas
A. Fajac, I. Simeonova, J. Leemput, M. Gabriel, A. Morin, V. Lejour, A. Hamon, J. Rakotopare, W. Vaysse-Zinkhofer, E. Eldawra, M. Pinskaya, A. Morillon, J.-C. Bourdon, B. Bardot, F. Toledo
The paper shows that male-specific protection against Myc-driven B-cell lymphomas is lost in mice lacking alternatively spliced p53 isoforms, identifying Ackr4 as a prognostic factor.
bioRxiv · Oct 13, 2023Cancer Biology