Eip74EF is a dominant modifier for ALS-FTD linked mutant VCP phenotypes in Drosophila, but not miR-34
M. R. Chalmers, J. Kim, N. C. Kim
The paper shows that Eip74EF rescues VCP mutant phenotypes in Drosophila, while miR-34 overexpression is lethal, suggesting different roles for miR-34 targets in ALS-FTD.
bioRxiv · Nov 20, 2020 · PreprintPathology