Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction
S. Subramanian, K. Gorday, K. Marcus, M. R. Orellana, P. Ren, X. R. Luo, M. E. O'Donnell, J. Kuriyan
The paper identifies a hydrogen-bonded junction in DNA polymerase clamp loaders that is critical for allosteric communication, preserved across diverse AAA+ ATPases.
bioRxiv · Dec 31, 2020Biophysics