S. Subramanian

Stimulation modulates cell assemblies linked with gene networks in the human temporal cortex ex vivo

The paper shows that stimulation increases firing rates in pyramidal cells and strengthens cell assemblies in the human temporal cortex, linked to gene networks involving excitatory neurons and non-neurons.

Genomic consequences of isolation and inbreeding in an island dingo population

This study analyzes whole-genome sequences of dingoes on an isolated island to assess the genomic impacts of inbreeding and small population size, finding elevated long runs of homozygosity and evidence of purging deleterious mutations.

Metabolic immaturity of newborns and breast milk bile acids are the central determinants of heightened neonatal vulnerability to norovirus diarrhea

This study identifies metabolic immaturity in newborns and maternal bile acids in breast milk as key factors increasing vulnerability to norovirus diarrhea.

Managed honey bee colony losses and causes during the active beekeeping season 2022/2023 in nine Sub-Saharan African countries

This study reports honey bee colony loss rates and risk factors in nine Sub-Saharan African countries during 2022/2023, highlighting theft, drought, and pests as major causes.

Single-nucleus and spatial landscape of the sub-ventricular zone in human glioblastoma

The paper builds a single-nucleus RNA-sequencing landscape of the SVZ in GBM patients and identifies therapeutic targets in the T_SVZ microenvironment.

Sex-specific sub-lethal effects of low virulence entomopathogenic fungi may boost the Sterile Insect Technique

This study evaluates the sub-lethal effects of Metarhizium anisopliae strains on Bactrocera dorsalis, showing sex-specific impacts that could enhance the Sterile Insect Technique.

Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer

This study develops and tests EREG-targeting ADCs showing efficacy in both RAS mutant and wildtype CRC, with high potency and safety in preclinical models.

Firefighter Helmets and Cervical Intervertebral Kinematics: An OpenSim-Based Biomechanical Study

This study uses OpenSim to analyze how different firefighter helmet designs affect cervical spine kinematics, finding that US-style helmets with superior center of mass cause more pronounced kinematic changes.

Adaptive capacity of a DNA polymerase clamp-loader ATPase complex

The paper shows that single point mutations can restore function to a defective DNA polymerase clamp-loader complex by compensating for reduced affinity between the clamp loader and the sliding clamp.

Allogeneic Tumor Cell-Derived Extracellular Vesicles Stimulate CD8 T Cell Response in Colorectal Cancer

This study shows that allogeneic modified CRC-derived extracellular vesicles lacking miR-424 stimulate CD8+ T cell responses and limit tumor growth in CT26 tumors.

A Vibrio cholerae viral satellite maximizes its spread and inhibits phage by remodeling hijacked phage coat proteins into small capsids

This study identifies TcaP as a protein that remodels phage ICP1 capsids into smaller structures, enhancing PLE satellite transduction and inhibiting ICP1.

Genomic signatures of bottleneck and founder effects in dingoes

This study examines genomic signatures of bottleneck and founder effects in dingoes by comparing their whole-genome diversity to other canines, finding lower diversity and higher deleterious mutations in dingoes.

Therapeutic and vaccine-induced cross-reactive antibodies with effector function against emerging Omicron variants

The paper shows that cross-reactive antibodies, like S309, retain effector functions against emerging Omicron variants despite reduced neutralization.

Fecal Microbiota Restoration Modulates the Microbiome in Inflammation-Driven Colorectal Cancer

The paper examines microbiome changes in inflammation-driven colorectal cancer using a mouse model, finding increased Akkermansia in microbiome-restored mice and elevated lipocalin-2 in unrestored animals.

Genomic footprints of bottleneck in landlocked salmon population

This study compares genomic data from landlocked and anadromous salmon populations to show reduced genetic diversity and increased homozygosity in landlocked populations, indicating a historical population bottleneck.

DNA bridging explains sub-diffusive movement of chromosomal loci in bacteria

The paper shows DNA bridging by NAPs explains sub-diffusive dynamics and rare rapid movements of chromosomal loci in bacteria, with a predicted lower bound on bridge lifetime.

Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the pre-hairpin intermediate of the spike protein

An antibody-drug conjugate targeting GPR56 demonstrates efficacy in preclinical models of colorectal cancer

This study develops an antibody-drug conjugate targeting GPR56 and shows it is effective against colorectal cancer models.

Yeast and Mammalian Epsins Use Different Determinants for Localization and Function: Role of Clathrin/AP2/Ubiquitin Binding Motifs and Poly-Glutamine Stretches

This study compares yeast and mammalian Epsin localization and function, identifying differences in binding determinants and highlighting the role of poly-glutamine stretches.

Host range expansion of Shigella phage Sf6 evolves through the dual roles of its tailspike

This paper shows that phage Sf6 evolves to expand its host range by mutating its tailspike protein to overcome inhibitory LPS interactions with serotype 2a2.

Loss of LGR5 through plasticity or gene ablation is associated with therapy resistance and enhanced MET-STAT3 signaling in colorectal cancer cells

This study shows that loss of LGR5 in colorectal cancer cells through plasticity or gene ablation activates MET-STAT3 signaling, leading to therapy resistance and suggesting new treatment strategies targeting plasticity.

Phylodynamic Pattern of Genetic Clusters, Paradigm Shift on Spatio-temporal Distribution of Clades, and Impact of Spike Glycoprotein Mutations of SARS-CoV-2 Isolates from India

The paper analyzes SARS-CoV-2 genomes from India to study clade distribution, Spike protein mutations, and their functional impacts on virulence and immune escape.

Loss of ACKR4 in tumor cells dysregulates dendritic cell migration to tumor-draining lymph nodes and T-cell priming

This study shows that loss of ACKR4 in colorectal cancer cells impairs dendritic cell migration and T-cell priming, leading to immune checkpoint blockade resistance.

The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2

This paper evaluates the in vitro and in vivo efficacy of dual-action monoclonal antibodies VIR-7831 and VIR-7832 against SARS-CoV-2, showing potent neutralization and reduced viral load in a hamster model.

Evidence for microbiome-dependent chilling tolerance in Sorghum

This study investigates how soil microbiomes affect sorghum's chilling tolerance, finding that microbial inoculation can enhance shoot biomass and leaf area under chilling stress in some genotypes.

Development of an exosomal gene signature to detect residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning

The paper develops a gene signature using exosomal RNA from canine osteosarcoma xenografts and machine learning to detect residual disease in dogs, showing improved remission outcomes in validation samples.

Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction

The paper identifies a hydrogen-bonded junction in DNA polymerase clamp loaders that is critical for allosteric communication, preserved across diverse AAA+ ATPases.

Physiological and transcriptomic response of Medicago truncatula to high and low benefit mycorrhizal fungi

This study compares the physiological and transcriptomic responses of Medicago truncatula to high and low benefit arbuscular mycorrhizal fungi, identifying gene expression differences linked to growth, nutrient uptake, and stress responses.

High resolution cryo EM analysis of HPV16 identifies minor structural protein L2 and describes capsid flexibility

This study presents a high-resolution 3.1 Å structure of HPV16 using cryo-EM, identifies the minor structural protein L2, and reveals capsid flexibility through inter-capsomer analysis.

Disruption of a GATA2, TAL1, ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells

The paper identifies a GATA2, TAL1, ERG regulatory circuit that promotes erythroid transition in both healthy and leukemic stem cells, showing its persistence in AML with minor alterations.