Maturation of the human B-cell receptor repertoire with age
M. Ghraichy, J. D. Galson, A. Kovaltsuk, V. von Niederhaeusern, J. Pachlopnik Schmid, M. Recher, A. Jauch, E. Miho, D. F. Kelly, C. M. Deane, J. Trueck
This study examines age-related changes in human B-cell receptor repertoires, finding significant shifts in immunoglobulin gene usage and self-reactive antibody frequencies during early life and aging.
bioRxiv · Dec 20, 2019 · PreprintImmunology