C. M. Deane

Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells

The paper designs a selective protein degradation system using bumped IMiD analogs and zinc-finger degrons to target specific proteins without affecting endogenous substrates.

A comparison of the binding sites of antibodies and single-domain antibodies

This study compares the binding sites of antibodies and single-domain antibodies, showing they target similar epitope sizes and shapes but differ in paratope interactions and framework residue importance.

Computationally profiling peptide:MHC recognition by T-cell receptors and T-cell receptor-mimetic antibodies

The paper profiles T-cell receptor-mimetic antibodies (TCRms) against pMHC complexes to quantify their TCR-likeness and identify molecular differences in antigen recognition.

Characterisation of the immune repertoire of a humanised transgenic mouse through immunophenotyping and high-throughput sequencing

The paper characterizes the immune repertoire of a humanised transgenic mouse using immunophenotyping and high-throughput sequencing, showing similarities to human BCR repertoires.

Different B cell subpopulations show distinct patterns in their IgH repertoire metrics

The paper compares IgH repertoire metrics across different B cell subpopulations and finds distinct patterns associated with their developmental stages and constant region positions.

Epitope profiling of coronavirus-binding antibodies using computational structural modelling

This paper introduces a computational method to profile epitopes of coronavirus-binding antibodies using structural modeling, revealing that sequence-dissimilar antibodies can bind the same epitope.

Humanization of antibodies using a machine learning approach on large-scale repertoire data

This paper develops a machine learning tool, Hu-mAb, to computationally humanize antibodies by predicting mutations that reduce immunogenicity, outperforming existing methods and validated against experimental data.

The allosteric modulation of Complement C5 by knob domain peptides

This study shows that knob domain peptides modulate complement C5 through allosteric mechanisms, revealing new therapeutic inhibitors and introducing knob domains as low molecular weight antibody fragments.

Novel Vβ specific germline contacts shape an elite controller T cell response

The paper identifies Vβ2-specific germline contacts that contribute to a focused T cell response against a parasite-derived peptide presented by H-2Ld, enhancing HIV control.

Deep sequencing of B cell receptor repertoires from COVID-19 patients reveals strong convergent immune signatures

The paper analyzes B cell receptor repertoires from COVID-19 patients to identify convergent immune signatures associated with disease outcome.

CoV-AbDab: the Coronavirus Antibody Database

The paper introduces CoV-AbDab, a database of antibodies against SARS-CoV-2 and related betacoronaviruses, providing metadata and analysis tools for research applications.

Maturation of the human B-cell receptor repertoire with age

This study examines age-related changes in human B-cell receptor repertoires, finding significant shifts in immunoglobulin gene usage and self-reactive antibody frequencies during early life and aging.

Structural Diversity of B-Cell Receptor Repertoires along the B-cell Differentiation Axis in Humans and Mice

The paper structurally characterizes B-cell receptor paratopes in humans and mice, showing structural differences across B-cell differentiation stages and conservation in naive repertoires.

The Therapeutic Antibody Profiler (TAP): Five Computational Developability Guidelines

The paper introduces TAP, a tool that identifies developability issues in therapeutic antibodies using five computational guidelines based on structural and charge properties.

Observed Antibody Space: a resource for data mining next generation sequencing of antibody repertoires

The paper introduces a resource called Observed Antibody Space (OAS) that curates and provides access to over half a billion antibody sequences from 53 studies for immune repertoire analysis.