J. D. Galson

Benchmarking and integrating human B-cell receptor genomic and antibody proteomic profiling

This study benchmarks and integrates bulk and single-cell BCR sequencing with antibody peptide sequencing to understand the humoral immune response.

Characterisation of the immune repertoire of a humanised transgenic mouse through immunophenotyping and high-throughput sequencing

The paper characterizes the immune repertoire of a humanised transgenic mouse using immunophenotyping and high-throughput sequencing, showing similarities to human BCR repertoires.

Different B cell subpopulations show distinct patterns in their IgH repertoire metrics

The paper compares IgH repertoire metrics across different B cell subpopulations and finds distinct patterns associated with their developmental stages and constant region positions.

Deep mining of early antibody response in COVID-19 patients yields potent neutralisers and reveals high level of convergence

The paper identifies potent neutralising antibodies from early COVID-19 patient samples and shows high convergence in antibody sequences across studies.

A high affinity human monoclonal antibody against Pfs230 binds multiple parasite stages and blocks oocyst formation in mosquitoes

The paper identifies a high-affinity human monoclonal antibody against Pfs230 that blocks oocyst formation in mosquitoes by targeting gamete surfaces.

Deep sequencing of B cell receptor repertoires from COVID-19 patients reveals strong convergent immune signatures

The paper analyzes B cell receptor repertoires from COVID-19 patients to identify convergent immune signatures associated with disease outcome.

Maturation of the human B-cell receptor repertoire with age

This study examines age-related changes in human B-cell receptor repertoires, finding significant shifts in immunoglobulin gene usage and self-reactive antibody frequencies during early life and aging.