CCR5/CXCR3 antagonist TAK-779 prevents diffuse alveolar damage of the lung in murine model of the SARS-CoV-2-related acute respiratory distress syndrome
A. Chernov, M. Rodionov, V. Kazakov, K. Ivanova, F. Mesheryakov, A. Kudriaeva, A. Gabibov, G. Telegin, A. Belogurov
This paper shows that TAK-779, a CCR5/CXCR3 antagonist, prevents diffuse alveolar damage in a murine model of SARS-CoV-2-induced ARDS by reducing mononuclear infiltration and cytokine levels.
bioRxiv · Nov 14, 2023Pathology